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Antibe Therapeutics
Antibe Therapeutics is a Toronto-based pharmaceutical company that develops inflammation-reducing drugs based on gaseous mediator technology.〔http://www.antibethera.com〕 Antibe was founded by John L. Wallace, also a co-founder of NicOx, the first company to develop drugs utilizing gaseous mediators.
==Products==
The mechanism of action of Antibe's drugs is the delivery of minute amounts of hydrogen sulfide to sites of inflammation within the human body.〔http://antibethera.com/products/scientific-foundation/〕 Hydrogen sulfide has been shown to enhance the resolution of injury and repair of damage arising from tissue inflammation. Antibe's lead drug, ATB-346, is a hydrogen sulfide-releasing derivative of naproxen, a commonly used non-steroidal anti-inflammatory drug (NSAID). ATB-346 is being developed to address osteoarthritis, although Antibe intends to broaden its application to rheumatoid arthritis and other diseases now treated with NSAIDs. Unlike standard naproxen, ATB-346 does not induce damage to the gastrointestinal tract.〔British Journal of Pharmacology http://antibethera.com/wp-content/uploads/2012/08/Wallace-et-al-2010-BJP-ATB-346-copy.pdf〕
In May 2014, the company announced that it had completed pre-clinical studies on ATB-346.〔http://online.wsj.com/article/PR-CO-20140505-901386.html〕 In late June 2014, following approval from Health Canada, the company announced the first human dosing for Phase I of its human clinical trials.〔http://www.marketwatch.com/story/antibe-therapeutics-announces-first-human-dose-of-atb-346-in-phase-i-clinical-trial-2014-06-26〕 In mid-January 2015, the company announced that clinical trials for its first drug were being suspended due to safety concerns; clinical trials were restarted in March 2015.〔http://www.antibethera.com/s/PressReleases.asp?ReportID=699894&_Type=Press-Releases&_Title=ANTIBE-THERAPEUTICS-PROVIDES-AN-UPDATE-ON-ITS-DATA-REVIEW-AND-CORPORATE-STR...〕 Antibe's products have not yet been approved by the US Food and Drug Administration.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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